In recent years, the combination of Radiesse® (a calcium hydroxylapatite-based dermal filler) and Profhilo® (a hybrid hyaluronic acid bioremodeler) has gained recognition among aesthetic physicians as a powerful synergistic approach for lower face rejuvenation. This innovative pairing is rooted in a complementary mechanism of action—while Radiesse provides structural volumization and lifting through its collagen-stimulating CaHA microspheres, Profhilo enhances dermal quality via deep hydration and bioremodeling properties of stabilized HA.
This dual-modality approach allows practitioners to address both structural and textural aspects of facial aging within a single treatment plan. Especially in the lower third of the face, where gravitational ptosis, skin laxity, and loss of mandibular definition are common, the strategic use of Radiesse and Profhilo combined can achieve natural, gradual, and highly customizable outcomes.
Moreover, clinical data and real-world application support the safety and efficacy of combining these two products when applied using evidence-based protocols and proper anatomical knowledge. As both are biostimulatory in nature, the goal is not just temporary filling, but long-term collagen induction and dermal renewal.
Practitioners are also finding that this combination enables more subtle, layered correction strategies, avoiding the risk of overfilling and enhancing patient satisfaction through progressive yet noticeable results. It is particularly valuable in patients seeking non-surgical facial harmonization, combining structural refinement with significant improvements in skin elasticity, texture, and hydration.
This article outlines evidence-based protocols, indications, anatomical considerations, and real-case guidance for the safe and effective use of Radiesse and Profhilo combined in jawline contouring and dermal quality enhancement.
Scientific Rationale: Why Combine Radiesse and Profhilo?
| Product | Type | Primary Benefit | Mechanism |
|---|---|---|---|
| Radiesse | Biostimulatory filler | Structural volumization + lift | CaHA microspheres stimulate collagen |
| Profhilo | Bioremodeling HA-based gel | Hydration + skin laxity reduction | High/low MW HA stimulates fibroblasts |
Synergy: While Radiesse restores volume and contour, Profhilo improves elasticity, hydration, and skin texture, making the combination ideal for lower facial rejuvenation.
Indications for Combination Use
- Jawline contour and definition (mandibular angle, pre-jowl sulcus)
- Skin laxity in the lower third
- Loss of elasticity and dermal dehydration
- Volume loss without overfilling
Injection Protocol (Suggested Clinical Approach)
Step 1: Structural support with Radiesse
- Dilution: Can be used undiluted or hyperdiluted (1:1 or 1:2 with saline/lidocaine) depending on skin quality.
- Technique: Cannula (25G or 27G), linear retrograde or fanning.
- Zones: Mandibular angle, body of mandible, pre-jowl.
Step 2: Dermal bioremodeling with Profhilo (5-point BAP method)
- Product: Profhilo (2 mL per side, depending on protocol)
- Technique: Bolus injections in specific subcutaneous points.
- Timing: Can be administered in the same session or 1–2 weeks after Radiesse.
Patient Selection Guidelines
| Criteria | Suitable? |
| Skin laxity grade I–II | ✅ Ideal |
| Excessive submental fat | ❌ Treat first |
| Recent threads or filler | ⚠️ Evaluate thoroughly |
| Good hydration + active fibroblasts | ✅ Enhances Profhilo effect |
Safety and Considerations
- Avoid overcorrection: both are stimulatory products
- Maintain aseptic technique, especially with Profhilo
- Space sessions if patient is prone to swelling or complications
- Do not mix in the same syringe
Clinical Case Example
Patient: Female, 48 years old, mild jowling, skin laxity, loss of contour.
- Session 1: 1.5 mL Radiesse (diluted 1:1) across jawline with cannula.
- Session 2 (Week 2): Profhilo 2 mL using BAP technique.
- Result: Improved mandibular definition, visible dermal hydration, natural texture.
Before and After (Simulation Suggested)
Use realistic photography or simulation to demonstrate progressive improvement in structure (Radiesse) and texture (Profhilo).
Image Suggestions
- Technical infographic – comparison of both products and their combined action
- Anatomical illustration – injection zones on jawline for each product
- Before/after visual – simulation of jawline enhancement
Evidence-Based References
Profhilo by IBSA: https://www.ibsaderma.comcians. The right choice depends on patient goals, timeline, and commitment to follow-up care.
De Boulle K, Heydenrych I. Biostimulatory fillers: a 2023 update. Aesth Surg J.
Cassuto D. Skin bioremodeling with hybrid hyaluronic acid: Profhilo clinical approach. J Cosmet Dermatol.
Radiesse official data: https://www.radiesse.com
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