In the world of modern aesthetic medicine, the demand for natural, soft, and harmonious lips has grown exponentially. Within this trend, Restylane Kysse has become a favorite choice among professionals for lip enhancement. This hyaluronic acid filler, developed by Galderma with XpresHAn Technology™, is designed to deliver volume, definition, and natural movement to the lips while preserving facial expressiveness.
Restylane Kysse stands out due to its advanced technique for natural lips, integrating smoothly with delicate lip tissue and allowing for enhanced shape and flexibility without compromising the patient’s ability to smile, speak, or express emotion. Its optimal gel balance and smooth texture offer predictable results, making it a preferred option for practitioners seeking subtle yet visible enhancement. Patients appreciate the natural feel and appearance, which makes the Restylane Kysse technique for natural lips especially valuable in cases where overcorrection is a concern.
This detailed clinical guide focuses on the Restylane Kysse technique for natural lips, from patient selection to post-treatment protocols, with a scientific, practical, and medical professional–oriented approach. It also addresses common challenges in lip augmentation, such as asymmetry, hydration, and projection, ensuring practitioners are well-equipped to deliver customized, reproducible outcomes using advanced Restylane Kysse lip techniques.
Chapter 1: Why Choose Restylane Kysse?
Clinical Advantages:
- Dynamic adaptability through XpresHAn Technology™
- Greater longevity compared to other lip fillers
- Smooth texture for precise, low-trauma injection
- High patient acceptance and satisfaction
Approved Indications:
- Lip volumization
- Vermilion border definition
- Mild asymmetry correction
- Deep rehydration
Chapter 2: Composition and XpresHAn Technology™
Restylane Kysse contains stabilized hyaluronic acid (20 mg/ml) with 0.3% lidocaine for enhanced patient comfort. Its XpresHAn Technology™ (also known as OBT – Optimal Balance Technology) allows natural tissue integration, enhancing elasticity and facial mobility.
Clinical results demonstrate effectiveness lasting up to 9–12 months with high aesthetic satisfaction, without compromising natural movement or functionality.
Chapter 3: Patient Assessment
Factors to Consider:
- Age, lip elasticity, hydration level
- Pre-existing asymmetries
- Past treatments
- Facial expression and smile dynamics
Ideal Patients:
- Over 21 years old with no active conditions
- Thin to moderately projected lips
- Realistic expectations
Chapter 4: Preparation and Advanced Injection Technique
Recommended Techniques:
- Linear anterograde or retrograde
- Fanning technique using a 30G or 27G needle
- 25G cannula for projection and profiling
Key Areas to Treat:
- Vermilion border
- Upper central tubercle
- Oral commissures
Suggested Starting Volume: 0.5 ml per lip, up to 1 ml total in conservative sessions

Chapter 5: Post-Treatment Care
Patient Instructions:
- Do not touch or massage for 12–24h
- Avoid hot beverages, intense exercise, and lip makeup for 48h
- Apply ice intermittently
Follow-Up:
- Check-up at 15 days
- Retouch if necessary
Chapter 6: Comparison with Other Lip Fillers
Product | Technology | Duration | Natural Movement |
---|---|---|---|
Restylane Kysse | XpresHAn | 9–12 months | Excellent |
Juvederm Volbella | Vycross | 6–9 months | Very Good |
Belotero Balance | CPM | 4–6 months | Moderate |
Chapter 7: Frequently Asked Questions (FAQ)
- Can it be combined with botulinum toxin? Yes
- Is the effect immediate? Yes
- Is it reversible? Yes (with hyaluronidase)
- Can it be used for gummy smile? Yes, with advanced technique
Chapter 8: Simulated Clinical Case
Patient: Female, 36 years old, thin lips, no previous fillers
Treatment: 1 ml Restylane Kysse divided between upper and lower lips. Linear technique with 30G needle.
Result: Natural volume, enhanced definition, and preserved smile.
Official Reference Sources:
Galderma – Restylane Kysse Product Page
Official manufacturer’s page with information on composition, technology, and clinical studies.
https://www.galderma.com
FDA – U.S. Food and Drug Administration
Information on the approval and safety of Restylane Kysse in the U.S.
https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=125476
Restylane Global (Galderma Aesthetics)
Medical information for professionals: indications, technologies, studies, and techniques.
https://www.restylane.com
Aesthetic practitioner, looking for certified original products?
Explore our professional catalog featuring Restylane, Juvederm, and more:
https://glowhealth.eu/product-category/brands/?orderby=popularity
———————————-
Support Your Patients with Trusted Natural Solutions
Explore our carefully curated selection of science-backed supplements and wellness products designed for clinical support.
Visit our professional store at glowhealth.eu